When a toe twitches, it’s because of an electrical misfire in the motor neuron unit in the muscle, but this isn’t the cause per se; it’s only the mechanism. Toe twitching is perfectly normal, but can have a variety of causes.
Because these muscles are so small, and the toe itself is such a small fixture of the body, it shouldn’t be any surprise that when it twitches, you can see it “jump.” If two toes twitch in unison, this is nothing at all to be worried about.
Twitching in these tiny muscles is completely normal and there is very little reason to fear you might have a disorder like ALS or MS.
"Yes, some people with benign fasciculations could experience them 24/7 (or so they say; I'm a little skeptical of that), but if nothing else is wrong, then I wouldn't probe further," adds Dr. Lafaye, assistant clinical professor of neurology at Tulane University School of Medicine, full time clinical staff and director of the neurophysiology lab at Ochsner Medical Center.
"I don't do any kind of a frequency count, because if a person doesn't have evidence of denervation which, if present, would indicate a MND, myelopathy, or some other condition, then it doesn't warrant any further neurologic evaluation."
- Tensing up the toes (anxiety, habit)
- Improper footwear, especially a tight toe box
- Pressure on a nerve (shoes, foot position while seated or lying down)
- Anxiety (not necessarily about what’s causing your toes to twitch, but anything that can cause apprehension)
- Insufficient calcium and magnesium intake